SCHEMBL7861184

SCHEMBL7861184

Nc1c([N+](=O)[O-])c([N+](=O)[O-])c([N+](=O)[O-])c([N+](=O)[O-])c1[N+](=O)[O-]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.39
PKM P14618 1/20 0.38
LMNA P02545 2/20 0.36
TSHR P16473 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
HTT P42858 2/20 0.36
POLB P06746 2/20 0.36
CYP3A4 P08684 2/20 0.34
GRIN2D O15399 1/20 0.34
GRIN3B O60391 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2A Q12879 1/20 0.34
GRIN2B Q13224 1/20 0.34
GRIN2C Q14957 1/20 0.34
GRIN3A Q8TCU5 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
USP2 O75604 1/20 0.33
KEAP1 Q14145 1/20 0.33
NFE2L2 Q16236 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29232798 0.97 ALDH1A1 (0.40) ALDH1A1PKMLMNATSHRTDP1
SCHEMBL223752 0.90 TSHR (0.40) ALDH1A1PKMLMNATSHRTDP1
SCHEMBL438677 0.90 ALDH1A1 (0.40) ALDH1A1PKMLMNATSHRTDP1
SCHEMBL10401073 0.88 ALDH1A1 (0.39) ALDH1A1PKMLMNATSHRTDP1
Barium SCHEMBL31718046 0.87 ALDH1A1 (0.39) ALDH1A1PKMLMNATSHRTDP1
SCHEMBL11040935 0.84 PKM (0.39) ALDH1A1PKMLMNATSHRTDP1
SCHEMBL11040704 0.83 PKM (0.42) ALDH1A1PKMLMNATSHRTDP1
SCHEMBL1194020 0.82 TSHR (0.45) ALDH1A1PKMLMNATSHRTDP1
SCHEMBL3876185 0.81 PKM (0.41) ALDH1A1PKMLMNATSHRTDP1
SCHEMBL15598673 0.80 TSHR (0.42) ALDH1A1PKMLMNATSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5149818-A Dissolving pentanitroaniline in solvent, adding alkali metal azide, preceipitation THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1992-09-22 US claimed
US-4262148-A Synthesis of hexanitrobenzene THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1981-04-14 US claimed
US-4248798-A New method for preparing pentanitroaniline and triaminotrinitrobenzenes from trinitrotoluene THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1981-02-03 US claimed
CN-115746021-B Synthesis method of 7-amino-6-nitrobenzofuroxan and isomer thereof 中国工程物理研究院化工材料研究所 2024-02-13 CN disclosed
CN-115746021-A Synthesis method of 7-amino-6-nitrobenzyl dioxidofurazan and isomer thereof 中国工程物理研究院化工材料研究所 2023-03-07 CN disclosed
US-6310253-B1 Preparation of 1,3,5-triamino-2,4,6-trinitrobenzene of submicron particle size THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF ENERGY 2001-10-30 US disclosed
US-6225503-B1 Preparation of 1,3,5-triamo-2,4,6-trinitrobenzene of submicron particle size THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY. 2001-05-01 US disclosed
US-6069277-A Amination of electrophilic aromatic compounds by vicarious nucleophilic substitution THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-05-30 US disclosed
EP-0835237-A1 AMINATION OF ELECTROPHILIC AROMATIC COMPOUNDS BY VICARIOUS NUCLEOPHILIC SUBSTITUTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-04-15 EP disclosed
US-5633406-A AMINATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-05-27 US disclosed
WO-1996035659-A1 AMINATION OF ELECTROPHILIC AROMATIC COMPOUNDS BY VICARIOUS NUCLEOPHILIC SUBSTITUTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-11-14 WO disclosed
US-4997987-A Preparation of 1,3,5-triamino-2,4,6-trinitrobenzene from 3,5-dichloroanisole THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) 1991-03-05 US disclosed
US-4952733-A Preparation of 1,3,5-triamino-2,4,6-trinitrobenzene from 3,5-dichloranisole THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) 1990-08-28 US disclosed
US-4434304-A Synthesis of trinitrophloroglucinol THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1984-02-28 US disclosed
US-4262148-A Synthesis of hexanitrobenzene THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1981-04-14 US disclosed
US-4262148-A Synthesis of hexanitrobenzene THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1981-04-14 US disclosed
US-4248798-A New method for preparing pentanitroaniline and triaminotrinitrobenzenes from trinitrotoluene THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1981-02-03 US disclosed
US-4248798-A New method for preparing pentanitroaniline and triaminotrinitrobenzenes from trinitrotoluene THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1981-02-03 US disclosed
US-4248798-A New method for preparing pentanitroaniline and triaminotrinitrobenzenes from trinitrotoluene THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1981-02-03 US disclosed
US-4099142-A Condensed explosive gas dynamic laser THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1978-07-04 US disclosed