Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29557477 | 0.92 | HPGD (0.59) | HPGDNPC1RAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL1599431 | 0.92 | HPGD (0.59) | HPGDNPC1RAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL7863787 | 0.90 | MRGPRX4 (0.56) | HPGDNPC1RAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL13434464 | 0.88 | SMPD1 (0.57) | HPGDNPC1RAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL3944668 | 0.87 | MRGPRX4 (0.59) | HPGDNPC1RAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL341137 | 0.83 | NPC1 (0.73) | HPGDNPC1RAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL184987 | 0.83 | SMPD1 (0.71) | HPGDNPC1RAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL8756076 | 0.80 | MRGPRX4 (0.61) | HPGDNPC1RAB9ASMN1; SMN2HDAC6 | |
| SCHEMBL4374620 | 0.80 | HPGD (0.64) | HPGDNPC1RAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL1600077 | 0.79 | MRGPRX4 (0.62) | HPGDNPC1RAB9ASMN1; SMN2SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753511-B1 | 4-INDOL-1-YL BUTYRIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ALPHA1-ADRENERGIC RECEPTORS AND TESTOSTERONE 5ALPHA-REDUCTASES | ZERIA PHARM CO LTD (JP) | 2001-07-11 | — | — | EP | disclosed |
| CN-1067985-C | Indole derivative and medicine containing the same | ZERIA PHARM CO LTD (JP) | 2001-07-04 | — | — | CN | disclosed |
| US-5760040-A | THERAPEUTIC AGENT FOR PROSTATIC HYPERTROPHY, URINATION DISORDER, ALOPECIA AND ACNE | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-02 | — | — | US | disclosed |
| CN-1145617-A | Indole derivatives and drugs containing the same | ZERIA PHARM CO LTD (JP) | 1997-03-19 | — | — | CN | disclosed |
| EP-0753511-A1 | INDOLE DERIVATIVE AND MEDICINE CONTAINING THE SAME | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-15 | — | — | EP | disclosed |