Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | RXRA | P19793 | 2/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1599431 | 0.95 | HPGD (0.59) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29557477 | 0.95 | HPGD (0.59) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1600077 | 0.92 | MRGPRX4 (0.62) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29556736 | 0.92 | MRGPRX4 (0.62) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10857748 | 0.91 | MRGPRX4 (0.61) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7861369 | 0.87 | HPGD (0.52) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL341137 | 0.87 | NPC1 (0.73) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL184987 | 0.87 | SMPD1 (0.71) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7863787 | 0.86 | MRGPRX4 (0.56) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4280782 | 0.85 | MRGPRX4 (0.74) | MRGPRX4HPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017848-A9 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009017848-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC. (US) | 2009-02-05 | — | — | WO | disclosed |