Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 8/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7859925 | 0.89 | HTR1A (0.46) | ABCB1HTR1ADRD2SIGMAR1KCNH2 | |
| SCHEMBL7854567 | 0.89 | MTNR1A (0.44) | ABCB1HTR1ADRD2NPC1RAB9A | |
| SCHEMBL7860104 | 0.87 | SMN1; SMN2 (0.41) | ABCB1HTR1ADRD2NPC1RAB9A | |
| SCHEMBL7854338 | 0.87 | HTR1A (0.36) | ABCB1HTR1ADRD2RAB9ASIGMAR1 | |
| SCHEMBL7861286 | 0.83 | MEN1 (0.42) | HTR1ANPC1RAB9ASIGMAR1ADRA1D | |
| SCHEMBL7861177 | 0.82 | PPIA (0.46) | HTR1ADRD2NPC1RAB9A | |
| SCHEMBL7861096 | 0.79 | KCNH2 (0.46) | SIGMAR1KCNH2 | |
| SCHEMBL7859923 | 0.78 | CYP19A1 (0.36) | ABCB1HTR1ADRD2NPC1RAB9A | |
| SCHEMBL7859944 | 0.78 | HTR1A (0.41) | ABCB1HTR1ADRD2NPC1RAB9A | |
| SCHEMBL7861121 | 0.75 | HRH3 (0.39) | SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625969-B1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMA INC (US) | 2001-03-07 | — | — | EP | disclosed |