Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | CNR1 | P21554 | 2/20 | 0.61 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23347882 | 0.89 | P4HTM (0.67) | RAB9ANPC1ALDH1A1KDM4ECNR1 | |
| SCHEMBL30834279 | 0.83 | RAB9A (0.73) | RAB9ANPC1ALDH1A1KDM4ECNR1 | |
| SCHEMBL21096059 | 0.83 | SMN1; SMN2 (0.70) | RAB9ANPC1ALDH1A1KDM4EP4HTM | |
| SCHEMBL22130325 | 0.81 | SMN1; SMN2 (0.72) | RAB9ANPC1ALDH1A1KDM4ECNR1 | |
| SCHEMBL30834320 | 0.81 | ALDH1A1 (1.00) | RAB9ANPC1ALDH1A1KDM4EP4HTM | |
| SCHEMBL7862687 | 0.81 | RAB9A (0.70) | RAB9ANPC1ALDH1A1KDM4ECNR1 | |
| SCHEMBL13210581 | 0.81 | ALDH1A1 (1.00) | RAB9ANPC1ALDH1A1KDM4EP4HTM | |
| SCHEMBL20176881 | 0.81 | TSHR (0.53) | RAB9ANPC1ALDH1A1KDM4ECNR1 | |
| SCHEMBL1910338 | 0.79 | ALDH1A1 (0.68) | RAB9ANPC1ALDH1A1KDM4ECNR1 | |
| SCHEMBL6450288 | 0.79 | ALDH1A1 (0.84) | RAB9ANPC1ALDH1A1KDM4EP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| WO-2010128058-A1 | DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |