SCHEMBL7861556

SCHEMBL7861556

COC(=O)c1ccc(C(=O)N2CCN(c3ncccc3NC(C)C)CC2)nc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G1B P04054 1/20 0.49
ATG4B Q9Y4P1 1/20 0.49
ADRA2A P08913 1/20 0.48
ADORA3 P0DMS8 1/20 0.48
CHRM1 P11229 1/20 0.48
MAOA P21397 1/20 0.48
TBXA2R P21731 1/20 0.48
OPRM1 P35372 1/20 0.48
MDH1 P40925 1/20 0.48
KCNH2 Q12809 1/20 0.48
ABCG2 Q9UNQ0 1/20 0.48
MAPK1 P28482 2/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
KMT2A Q03164 1/20 0.42
KDM4E B2RXH2 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
HRH3 Q9Y5N1 2/20 0.40
ALDH1A1 P00352 2/20 0.40
P2RY12 Q9H244 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7861522 0.91 ADRA2A (0.49) PLA2G1BATG4BADRA2AADORA3CHRM1
SCHEMBL7866488 0.90 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8711887 0.89 ADRA2A (0.51) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL7866501 0.88 KCNH2 (0.45) PLA2G1BATG4BADRA2AADORA3CHRM1
SCHEMBL7873078 0.88 PLA2G1B (0.45) PLA2G1BATG4BADRA2AADORA3CHRM1
SCHEMBL7868160 0.87 MEN1 (0.47) PLA2G1BATG4BADRA2AADORA3CHRM1
SCHEMBL7866455 0.87 KCNH2 (0.47) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL7873013 0.87 PRMT5 (0.47) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL7869019 0.86 ADRA2A (0.44) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL7873073 0.86 NAMPT (0.45) PLA2G1BATG4BADRA2AADORA3CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6306860-B1 ANTIVIRAL ACTIVITIES AGAINST HEPATATIS B AS WELL AS HUMAN IMMUNODEFICIENCY VIRUS DONG WHA PHARM. INC. CO., LTD. (KR) 2001-10-23 US disclosed
WO-1999058526-A1 NOVEL 2,5-PYRIDINEDICARBOXYLIC ACID DERIVATIVES DONG WHA PHARM. IND. CO., LTD. (KR) 1999-11-18 WO disclosed