Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CPS1 | P31327 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5998156 | 0.94 | LMNA (0.46) | MAPTKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5997708 | 0.82 | NPC1 (0.47) | MAPTKDM4ELMNAP2RX1TMPRSS4 | |
| SCHEMBL5995248 | 0.77 | MAPT (0.63) | MAPTKDM4ELMNASMN1; SMN2MEN1 | |
| SCHEMBL3491420 | 0.76 | HSD11B1 (0.50) | MAPTKDM4ELMNAP2RX1TMPRSS4 | |
| SCHEMBL17080255 | 0.75 | KDM4E (0.48) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL5981077 | 0.74 | KMT2A (0.39) | MAPTKDM4ELMNAP2RX1TMPRSS4 | |
| SCHEMBL5996935 | 0.73 | CA12 (0.38) | MAPTKDM4ELMNAALDH1A1TP53 | |
| SCHEMBL4126643 | 0.72 | NPC1 (0.53) | MAPTKDM4ELMNAP2RX1TMPRSS4 | |
| SCHEMBL5998657 | 0.71 | CA12 (0.42) | SMN1; SMN2GAA | |
| SCHEMBL4129937 | 0.71 | MAPT (0.55) | MAPTKDM4ELMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076650-A1 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | Pfizer Products Inc. (US) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999055680-A1 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-11-04 | — | — | WO | disclosed |