Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.53 |
| ▸ | NPC1 | O15118 | 10/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4137199 | 0.85 | ACP1 (0.54) | RAB9ANPC1MAPTATAD2PKM | |
| SCHEMBL4132956 | 0.79 | MAPT (0.54) | RAB9ANPC1MAPTATAD2PKM | |
| SCHEMBL19724747 | 0.75 | MAPT (0.58) | RAB9ANPC1MAPTATAD2PKM | |
| SCHEMBL2837341 | 0.75 | MAPT (0.55) | RAB9ANPC1MAPTATAD2PKM | |
| SCHEMBL12354892 | 0.73 | MAPT (0.54) | RAB9ANPC1MAPTATAD2PKM | |
| SCHEMBL10812910 | 0.70 | RAB9A (0.68) | RAB9ANPC1MAPTATAD2PKM | |
| SCHEMBL16238270 | 0.70 | RAB9A (0.64) | RAB9ANPC1MAPTATAD2PKM | |
| SCHEMBL24803898 | 0.69 | RAB9A (1.00) | RAB9ANPC1MAPTPKMALDH1A1 | |
| SCHEMBL155142 | 0.69 | RAB9A (0.57) | RAB9ANPC1MAPTPKMALDH1A1 | |
| SCHEMBL2631604 | 0.68 | RAB9A (0.56) | RAB9ANPC1MAPTATAD2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143955-A3 | A COMBINATION OF FBPase INHIBITORS AND INSULIN SENSITIZERS FOR THE TREATMENT OF DIABETES | Metabasis Therapeutics Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1143955-A2 | A COMBINATION OF FBPase INHIBITORS AND INSULIN SENSITIZERS FOR THE TREATMENT OF DIABETES | Metabasis Therapeutics Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000038666-A2 | A COMBINATION OF FBPase INHIBITORS AND INSULIN SENSITIZERS FOR THE TREATMENT OF DIABETES | METABASIS THERAPEUTICS, INC. (US) | 2000-07-06 | — | — | WO | disclosed |