Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | KMO | O15229 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008321 | 1.00 | MAPK1 (0.75) | MAPK1SMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL11135147 | 0.88 | ALDH1A1 (0.77) | MAPK1SMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL11139506 | 0.88 | ALDH1A1 (0.77) | MAPK1SMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL11135285 | 0.87 | ALDH1A1 (0.75) | MAPK1SMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL11137490 | 0.87 | ALDH1A1 (0.75) | MAPK1SMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL23182640 | 0.86 | MAPK1 (0.73) | MAPK1SMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL5717757 | 0.86 | MAPK1 (1.00) | MAPK1SMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL7019074 | 0.83 | ALDH1A1 (0.66) | MAPK1SMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL2947194 | 0.83 | HPGD (0.73) | MAPK1SMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL7861839 | 0.83 | MAPK1 (0.64) | MAPK1SMN1; SMN2ALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067928-A4 | METHODS FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1067928-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051228-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 1999-10-14 | — | — | WO | disclosed |