Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | MIF | P14174 | 1/20 | 0.63 |
| ▸ | IDO1 | P14902 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204691 | 0.85 | IDO1 (0.79) | HPGDMAPK1TSHRUSP2MIF | |
| SCHEMBL13995838 | 0.85 | HPGD (0.71) | HPGDMAPK1TSHRUSP2IDO1 | |
| SCHEMBL4414345 | 0.85 | HPGD (1.00) | HPGDMAPK1TSHRUSP2MIF | |
| Benzene SCHEMBL7861838 | 0.83 | MAPK1 (0.75) | HPGDMAPK1TSHRUSP2ALDH1A1 | |
| SCHEMBL2008321 | 0.83 | MAPK1 (0.75) | HPGDMAPK1TSHRUSP2ALDH1A1 | |
| SCHEMBL5418750 | 0.82 | TSPO (0.58) | — | |
| SCHEMBL11192533 | 0.81 | MAPT (0.53) | HPGDMAPK1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6717405 | 0.81 | HPGD (0.66) | HPGDMAPK1TSHRUSP2IDO1 | |
| SCHEMBL4427310 | 0.81 | LMNA (0.71) | HPGDLMNA | |
| SCHEMBL29004242 | 0.81 | LMNA (0.71) | HPGDMAPK1TSHRUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240408107-A1 | LACTAM PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2024-12-12 | — | — | US | disclosed |
| US-20240158386-A1 | BENZOXAZOLONE INHIBITORS OF INFLAMMASOMES | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2024-05-16 | — | — | US | disclosed |
| WO-2023060134-A1 | LACTAM PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2023-04-13 | — | — | WO | disclosed |
| WO-2022187804-A1 | BENZOXAZOLONE INHIBITORS OF INFLAMMASOMES | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-09-09 | — | — | WO | disclosed |
| EP-2768822-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARM SPA (IT) | 2017-12-06 | — | — | EP | disclosed |
| EP-2809668-B1 | 4-(BENZOIMIDAZOL-2-YL)-THIAZOLE COMPOUNDS AND RELATED AZA DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2017-04-12 | — | — | EP | disclosed |
| US-9266876-B2 | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-02-23 | — | — | US | disclosed |
| US-9024027-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-9024027-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-8999974-B2 | Acyl piperazine derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2015-04-07 | — | — | US | disclosed |
| WO-2004091604-A1 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS OF PREPARATION | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-28 | — | — | WO | disclosed |
| WO-2004089302-A2 | POSH POLYPEPTIDES, COMPLEXES AND RELATED METHODS | PROTEOLOGICS, INC. (US) | 2004-10-21 | — | — | WO | disclosed |
| US-20040209936-A1 | Compounds that modulate PPAR activity and methods of preparation | BRATTON LARRY D (US) | 2004-10-21 | — | — | US | disclosed |
| WO-2004078130-A2 | POSH INTERACTING PROTEINS AND RELATED METHODS | PROTEOLOGICS, INC. (US) | 2004-09-16 | — | — | WO | disclosed |
| WO-2004073609-A2 | POSH ASSOCIATED KINASES AND RELATED METHODS | PROTEOLOGICS, INC. (US) | 2004-09-02 | — | — | WO | disclosed |
| CN-1492874-A | Macrolide antibiotics | — | 2004-04-28 | — | — | CN | disclosed |
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240158386-A1 | BENZOXAZOLONE INHIBITORS OF INFLAMMASOMES | NLRP3, NLRP1, PYCARD | HPGD 3270/4885MAPK1 1857/4885TSHR 4431/4885 |
| US-20040209936-A1 | Compounds that modulate PPAR activity and methods of preparation | PPARA, PPARG, PPARD | HPGD 691/4885MAPK1 1366/4885TSHR 613/4885 |
| US-20240408107-A1 | LACTAM PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | PDK1, PKM, PDK3 | HPGD 914/4885MAPK1 706/4885TSHR 3161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.