Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | THRA | P10827 | 6/20 | 0.68 |
| ▸ | THRB | P10828 | 6/20 | 0.68 |
| ▸ | PLA2G4B | P0C869 | 6/20 | 0.67 |
| ▸ | RARB | P10826 | 3/20 | 0.63 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591116 | 1.00 | TP53 (0.69) | TP53TSHRTHRATHRBPLA2G4B | |
| SCHEMBL1437711 | 1.00 | TP53 (0.69) | TP53TSHRTHRATHRBPLA2G4B | |
| SCHEMBL7861703 | 1.00 | TP53 (0.69) | TP53TSHRTHRATHRBPLA2G4B | |
| SCHEMBL14644865 | 1.00 | TP53 (0.69) | TP53TSHRTHRATHRBPLA2G4B | |
| SCHEMBL4629110 | 1.00 | TP53 (0.69) | TP53TSHRTHRATHRBPLA2G4B | |
| SCHEMBL2356907 | 0.98 | TP53 (0.66) | TP53TSHRTHRATHRBPLA2G4B | |
| SCHEMBL5055145 | 0.95 | L3MBTL1 (0.65) | TP53TSHRTHRATHRBPLA2G4B | |
| SCHEMBL7371927 | 0.94 | RARB (0.68) | TP53TSHRTHRATHRBPLA2G4B | |
| SCHEMBL11657851 | 0.90 | PLA2G4B (0.58) | TP53TSHRTHRATHRBPLA2G4B | |
| SCHEMBL5057170 | 0.88 | L3MBTL1 (0.70) | TP53TSHRTHRATHRBPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923529-B1 | SUBSTITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER AG (US) | 2001-09-19 | — | — | EP | disclosed |
| EP-0923529-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | Bayer Corporation (US) | 1999-06-23 | — | — | EP | disclosed |
| US-5863915-A | ENZYME INHIBITORS FOR BONES AND JOINTS | BAYER CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1997043237-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |
| US-4204867-A | THIAZOLE OR IMIDAZOLE FOUR EQUILVALENT COUPLERS | AGFA-GEVAERT, A.G. (DE) | 1980-05-27 | — | — | US | disclosed |
| US-4183752-A | DEVELOPMENT INHIBITOR RELEASING THIOETHERS | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1980-01-15 | — | — | US | disclosed |