Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SENP1 | Q9P0U3 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862007 | 1.00 | MMP13 (0.47) | MMP13L3MBTL1TDP1RAB9APPARG | |
| SCHEMBL7380420 | 0.93 | EPHX2 (0.50) | MMP13L3MBTL1TDP1RAB9APPARG | |
| SCHEMBL7380417 | 0.93 | EPHX2 (0.50) | MMP13L3MBTL1TDP1RAB9APPARG | |
| SCHEMBL7380693 | 0.87 | F10 (0.51) | MMP13PPARGEPHX2HDAC2HDAC8 | |
| SCHEMBL7861961 | 0.83 | SENP1 (0.49) | MMP13RAB9APPARGEPHX2ROCK2 | |
| SCHEMBL7380699 | 0.82 | PPARG (0.44) | MMP13PPARGEPHX2HDAC2HDAC8 | |
| SCHEMBL7379315 | 0.82 | MEN1 (0.51) | L3MBTL1TDP1RAB9AHDAC2LMNA | |
| SCHEMBL7382175 | 0.82 | MEN1 (0.51) | L3MBTL1TDP1RAB9AHDAC2LMNA | |
| SCHEMBL7856500 | 0.82 | SENP1 (0.48) | MMP13RAB9APPARGEPHX2ROCK2 | |
| SCHEMBL7862050 | 0.80 | PPARG (0.44) | MMP13PPARGEPHX2ROCK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |