Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 9/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8692148 | 1.00 | DRD3 (0.54) | DRD3FYNALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL9776918 | 0.90 | DRD3 (0.61) | DRD3FYNALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL9441640 | 0.82 | DRD3 (0.53) | DRD3DRD2 | |
| SCHEMBL7864930 | 0.82 | DRD3 (0.61) | DRD3FYNDRD2 | |
| SCHEMBL8900096 | 0.82 | DRD3 (0.61) | DRD3FYNDRD2 | |
| SCHEMBL17822689 | 0.82 | DRD3 (0.55) | DRD3FYNALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL7854607 | 0.78 | DRD3 (0.51) | DRD3FYNALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL8694462 | 0.78 | DRD3 (0.58) | DRD3FYNALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL8691897 | 0.78 | DRD3 (0.54) | DRD3FYNALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL8690081 | 0.76 | ALDH1A1 (0.69) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807101-B1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | UPJOHN CO (US) | 2001-06-13 | — | — | EP | disclosed |
| US-5936000-A | 2-aminoindans as selective dopamine D3 ligands | PHARMACIA & UPJOHN COMPANY (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0807101-A1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-11-19 | — | — | EP | disclosed |
| WO-1996023760-A1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1996-08-08 | — | — | WO | disclosed |