Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 16/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7860278 | 0.85 | LMNA (0.59) | ABCB1ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL7854831 | 0.84 | LMNA (0.58) | ALDH1A1LMNAALOX15TSHRGAA | |
| SCHEMBL7854934 | 0.84 | LMNA (0.67) | ALDH1A1LMNAALOX15TSHRGAA | |
| SCHEMBL7861690 | 0.82 | CYP2D6 (0.71) | ABCB1ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL7864576 | 0.81 | LMNA (0.55) | ABCB1ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL7862516 | 0.81 | MAPT (0.62) | ALDH1A1LMNAALOX15TSHRGAA | |
| SCHEMBL7861453 | 0.78 | LMNA (0.57) | ALDH1A1LMNAALOX15TSHRGAA | |
| SCHEMBL8638802 | 0.78 | ABCB1 (0.85) | ABCB1ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL7289913 | 0.78 | ABCB1 (0.78) | ABCB1ALDH1A1LMNAALOX15TSHR | |
| SCHEMBL7855115 | 0.77 | LMNA (0.56) | ALDH1A1LMNAALOX15TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837680-B1 | USE OF PHENOXY PYRIDINE DERIVATIVES FOR THE TREATMENT OF ILLNESSES CAUSED BY DISORDERS OF THE DOPAMINE SYSTEM | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | EP | disclosed |
| EP-0837680-A1 | USE OF PHENOXY PYRIDINE DERIVATIVES FOR THE TREATMENT OF ILLNESSES CAUSED BY DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1998-04-29 | — | — | EP | disclosed |
| WO-1996041629-A1 | USE OF PHENOXY PYRIDINE DERIVATIVES FOR THE TREATMENT OF ILLNESSES CAUSED BY DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-27 | — | — | WO | disclosed |