Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 17/20 | 0.85 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | THRB | P10828 | 1/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | HTR7 | P34969 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8654803 | 0.88 | ABCB1 (0.72) | ABCB1TP53GAATHRBKMT2A | |
| SCHEMBL7289913 | 0.83 | ABCB1 (0.78) | ABCB1USP2ALDH1A1LMNATP53 | |
| SCHEMBL8610306 | 0.81 | MAPT (0.70) | ABCB1USP2ALDH1A1LMNATP53 | |
| SCHEMBL10508713 | 0.80 | MAPT (0.62) | ABCB1GAAKMT2AHTR7 | |
| SCHEMBL3641483 | 0.80 | MAPT (0.62) | ABCB1TP53GAATHRBKMT2A | |
| SCHEMBL7713577 | 0.79 | MAPT (1.00) | USP2ALDH1A1LMNATP53GAA | |
| SCHEMBL8613867 | 0.79 | MAPT (0.82) | ALDH1A1LMNAGAAALOX15TSHR | |
| SCHEMBL7862476 | 0.78 | ABCB1 (0.65) | ABCB1USP2ALDH1A1LMNATP53 | |
| SCHEMBL9815965 | 0.77 | HTR7 (0.76) | ABCB1ALDH1A1LMNAALOX15KMT2A | |
| SCHEMBL9015935 | 0.77 | ALDH1A1 (0.74) | ALDH1A1LMNAGAAALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833639-A1 | PHENOXY PIPERAZINE DERIVATIVES FOR TREATING DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1998-04-08 | — | — | EP | disclosed |
| US-5614526-A | IN TREATING DISORDERS OF THE DOPAMINE SYSTEM | HOFFMANN-LA ROCHE INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996041630-A1 | PHENOXY PIPERAZINE DERIVATIVES FOR TREATING DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-27 | — | — | WO | disclosed |