SCHEMBL7862783

SCHEMBL7862783

CCOC(=O)C(CCCc1ccccc1)(CC(=O)c1ccc(Br)cc1)C(=O)OCC

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.45
POLB P06746 1/20 0.45
ALDH1A1 P00352 3/20 0.44
LMNA P02545 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HSP90AA1 P07900 2/20 0.43
HDAC3 O15379 1/20 0.43
TDP1 Q9NUW8 2/20 0.42
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
HPGD P15428 2/20 0.41
MMP8 P22894 1/20 0.41
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
KMT2A Q03164 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1748056 0.93 NPSR1 (0.47) NPSR1POLBALDH1A1LMNACYP1A2
SCHEMBL12430069 0.88 NPSR1 (0.45) NPSR1POLBALDH1A1LMNACYP1A2
SCHEMBL4232007 0.85 NPSR1 (0.52) NPSR1POLBALDH1A1LMNACYP1A2
SCHEMBL7861847 0.84 HSP90AA1 (0.50) ALDH1A1CYP2C19SMN1; SMN2HSP90AA1HDAC3
SCHEMBL1747922 0.82 ALDH1A1 (0.51) NPSR1POLBALDH1A1LMNACYP1A2
SCHEMBL7370659 0.82 POLB (0.42) NPSR1POLBALDH1A1KMT2AMAPT
SCHEMBL1747934 0.79 ALDH1A1 (0.48) NPSR1POLBALDH1A1LMNACYP1A2
SCHEMBL11133472 0.77 PTPRC (0.46) NPSR1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL3257456 0.76 MMP8 (0.58) POLBALDH1A1LMNASMN1; SMN2HDAC3
SCHEMBL11279345 0.75 PTPRC (0.45) ALDH1A1LMNACYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923529-B1 SUBSTITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS BAYER AG (US) 2001-09-19 EP disclosed
CN-1225620-A Substituted 4-arylbutanoic acid derivatives as matrix metalloproteinase inhibitors BAYER AG (US) 1999-08-11 CN disclosed
EP-0923529-A1 SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS Bayer Corporation (US) 1999-06-23 EP disclosed
US-5863915-A ENZYME INHIBITORS FOR BONES AND JOINTS BAYER CORPORATION (US) 1999-01-26 US disclosed
WO-1997043237-A1 SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS BAYER CORPORATION (US) 1997-11-20 WO disclosed