Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 20/20 | 0.53 |
| ▸ | MMP13 | P45452 | 20/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 19/20 | 0.53 |
| ▸ | MMP1 | P03956 | 13/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862879 | 0.92 | MMP9 (0.64) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL6814792 | 0.78 | ADAM17 (0.82) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL6810778 | 0.78 | MMP9 (0.81) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL6814746 | 0.76 | ADAM17 (0.68) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL6819210 | 0.75 | ADAM17 (0.65) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL6818857 | 0.74 | ADAM17 (0.64) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL6810934 | 0.74 | ADAM17 (0.82) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL6814733 | 0.73 | ADAM17 (0.81) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL6814930 | 0.72 | ADAM17 (0.61) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL6819057 | 0.72 | ADAM17 (0.76) | MMP9MMP13ADAM17MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144369-A2 | ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000044710-A2 | ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |