Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL256074 | 0.78 | SNCA (0.52) | SNCAHDAC8KDR | |
| SCHEMBL8031390 | 0.76 | HPGDS (0.54) | SNCACYP2A6HPGDS | |
| SCHEMBL928439 | 0.74 | SNCA (0.55) | SNCAHPGDSKDR | |
| SCHEMBL13142474 | 0.71 | SNCA (0.66) | SNCAKDR | |
| SCHEMBL22466129 | 0.71 | SNCA (0.56) | SNCAHDAC8 | |
| SCHEMBL25382795 | 0.71 | SNCA (0.56) | SNCAHDAC8 | |
| SCHEMBL5561901 | 0.71 | SNCA (0.51) | SNCAHPGDSKDR | |
| SCHEMBL20641446 | 0.71 | SNCA (0.56) | SNCA | |
| SCHEMBL10013471 | 0.71 | SNCA (0.51) | SNCAHDAC8 | |
| SCHEMBL14157145 | 0.71 | SNCA (0.66) | SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1343215-A | 6-O-substituted macrolides with antibacterial activity | ABBOTT LAB (US) | 2002-04-03 | — | — | CN | disclosed |
| EP-1161438-A1 | 6-O-SUBSTITUTED MACROLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055168-A1 | 6-O-SUBSTITUTED MACROLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 2000-09-21 | — | — | WO | disclosed |
| US-6054435-A | 6-O-substituted macrolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2000-04-25 | — | — | US | disclosed |