Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL975117 | 0.78 | ALDH1A1 (0.68) | MAPTNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL5705801 | 0.77 | TSHR (0.59) | MAPTNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL7869833 | 0.77 | NPC1 (0.46) | MAPTNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL7869925 | 0.77 | MAPT (0.50) | MAPTNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL2760495 | 0.75 | MAPT (0.62) | MAPTNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL11279444 | 0.74 | MAPT (0.54) | MAPTRAB9AALDH1A1TDP1KMT2A | |
| Hydrochloric Acid SCHEMBL11299680 | 0.74 | MAPT (0.60) | MAPTNPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL7875080 | 0.73 | MAPT (0.50) | MAPTTSHRALDH1A1TDP1KMT2A | |
| SCHEMBL7875084 | 0.73 | MAPT (0.50) | MAPTTSHRALDH1A1TDP1KMT2A | |
| SCHEMBL29696138 | 0.73 | TSHR (0.67) | MAPTTSHRALDH1A1TDP1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1084747-C | Pyrrolobenzazepine * derivatives as neuroactive agents | ZENECA LTD (GB) | 2002-05-15 | — | — | CN | disclosed |
| US-6313290-B1 | Azolobenzazepine derivatives and compositions and method of use thereof | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| US-6124281-A | TREATING STROKES | ZENECA LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| CN-1224424-A | Azolobenzazepine derivs. as neurologically active agents | ZENECA LTD (GB) | 1999-07-28 | — | — | CN | disclosed |