Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27371673 | 0.82 | HPGD (0.44) | NPC1RAB9AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL27452003 | 0.82 | ALDH1A1 (0.49) | TSHRALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL7863137 | 0.77 | MAPT (0.52) | NPC1RAB9ATSHRALDH1A1CTSD | |
| SCHEMBL975117 | 0.74 | ALDH1A1 (0.68) | NPC1RAB9ATSHRALDH1A1CTSD | |
| SCHEMBL5705801 | 0.73 | TSHR (0.59) | NPC1RAB9ATSHRALDH1A1CTSD | |
| SCHEMBL29696138 | 0.72 | TSHR (0.67) | TSHRALDH1A1CTSDCYP1A2CYP3A4 | |
| SCHEMBL30727560 | 0.72 | TSHR (0.67) | TSHRALDH1A1CTSDCYP1A2CYP3A4 | |
| SCHEMBL78205 | 0.72 | TSHR (0.67) | TSHRALDH1A1CTSDCYP1A2CYP3A4 | |
| SCHEMBL6254946 | 0.71 | NPC1 (0.53) | NPC1RAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL411359 | 0.71 | ALDH1A1 (0.59) | NPC1RAB9ATSHRALDH1A1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313290-B1 | Azolobenzazepine derivatives and compositions and method of use thereof | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| US-6124281-A | TREATING STROKES | ZENECA LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0888350-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032883-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |