Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 11/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500073 | 0.89 | MAPT (0.49) | MAPTLMNASMN1; SMN2BCHEMAPK1 | |
| SCHEMBL7377637 | 0.81 | MAPT (0.55) | MAPTLMNASMN1; SMN2BCHEHDAC6 | |
| SCHEMBL7856474 | 0.81 | SIRT2 (0.51) | MAPTLMNASMN1; SMN2BCHEMAPK1 | |
| SCHEMBL7856497 | 0.79 | MAPT (0.50) | MAPTLMNASMN1; SMN2BCHEHDAC6 | |
| SCHEMBL6366986 | 0.78 | PLA2G10 (0.47) | MAPTLMNASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL8531696 | 0.77 | MAPT (0.48) | MAPTLMNASMN1; SMN2BCHEMAPK1 | |
| Hydrochloric Acid SCHEMBL6368863 | 0.77 | PLA2G10 (0.46) | MAPTLMNASMN1; SMN2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6773326 | 0.77 | PLA2G10 (0.46) | MAPTLMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL19426798 | 0.77 | PLK4 (0.48) | LMNASMN1; SMN2BCHEKMT2A | |
| SCHEMBL7863196 | 0.77 | MAPT (0.50) | MAPTLMNASMN1; SMN2BCHEMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |