Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 12/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531696 | 0.86 | MAPT (0.48) | MAPTLMNASMN1; SMN2BCHEITGB3 | |
| SCHEMBL7863198 | 0.85 | MAPT (0.44) | MAPTLMNASMN1; SMN2BCHEITGB3 | |
| SCHEMBL7863288 | 0.84 | SIRT2 (0.48) | MAPTLMNASMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL7856433 | 0.82 | ITGB3 (0.54) | MAPTSMN1; SMN2ITGB3ITGA2BSIRT2 | |
| SCHEMBL7862015 | 0.81 | MAPT (0.51) | MAPTLMNASMN1; SMN2ITGB3SIRT2 | |
| SCHEMBL7455765 | 0.81 | ITGB3 (0.58) | ITGB3ITGA2BHDAC6SIRT2 | |
| SCHEMBL7377637 | 0.80 | MAPT (0.55) | MAPTLMNASMN1; SMN2BCHEITGB3 | |
| SCHEMBL7856464 | 0.78 | TP53 (0.49) | LMNABCHEITGB3ITGA2BSIRT2 | |
| SCHEMBL7863172 | 0.77 | MAPT (0.51) | MAPTLMNASMN1; SMN2BCHEHDAC6 | |
| SCHEMBL7864274 | 0.77 | LMNA (0.43) | MAPTLMNAITGB3ITGA2BSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |