Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 4/20 | 0.60 |
| ▸ | HRH1 | P35367 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.60 |
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | DRD5 | P21918 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320462 | 0.81 | TSHR (0.63) | TSHRTDP1DRD1HRH1DRD3 | |
| SCHEMBL14970678 | 0.81 | MEN1 (0.73) | TSHRTDP1DRD1HRH1DRD3 | |
| SCHEMBL14970672 | 0.81 | MEN1 (0.73) | TSHRTDP1DRD1HRH1DRD3 | |
| SCHEMBL1027777 | 0.80 | LTA4H (0.71) | TSHRTDP1DRD1HRH1DRD3 | |
| SCHEMBL8351940 | 0.80 | TDP1 (0.97) | TSHRTDP1DRD1HRH1DRD3 | |
| SCHEMBL14970676 | 0.80 | TSHR (1.00) | TSHRTDP1DRD1HRH1DRD3 | |
| SCHEMBL9911421 | 0.80 | TSHR (1.00) | TSHRTDP1DRD1HRH1DRD3 | |
| SCHEMBL14970697 | 0.80 | TDP1 (0.97) | TSHRTDP1DRD1HRH1DRD3 | |
| SCHEMBL14397182 | 0.80 | TSHR (0.67) | TSHRTDP1DRD1HRH1DRD3 | |
| SCHEMBL14970683 | 0.80 | L3MBTL1 (0.71) | TSHRTDP1DRD1HRH1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986556-A4 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS | LILLY CO ELI (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-0986556-A1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998045287-A1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1998-10-15 | — | — | WO | disclosed |