Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561794 | 0.89 | FNTA (0.40) | FNTAFNTBPGGT1BPTGS2CYP19A1 | |
| SCHEMBL7563915 | 0.84 | FNTA (0.51) | FNTAFNTBPGGT1BPTGS2CYP19A1 | |
| SCHEMBL7662081 | 0.83 | CYP51A1 (0.40) | FNTAFNTBPGGT1BPTGS2NAMPT | |
| SCHEMBL7571016 | 0.80 | CYP19A1 (0.46) | FNTAFNTBPGGT1BPTGS2CYP19A1 | |
| SCHEMBL7565371 | 0.77 | NAMPT (0.35) | NAMPTSLC6A4SLC6A3 | |
| SCHEMBL7562219 | 0.76 | FNTA (0.47) | FNTAFNTBPGGT1BPTGS2CYP19A1 | |
| SCHEMBL7569644 | 0.76 | FNTA (0.54) | FNTAFNTBPGGT1B | |
| SCHEMBL8224926 | 0.75 | FNTA (0.43) | FNTAFNTBPGGT1BPTGS2CYP19A1 | |
| SCHEMBL7563110 | 0.74 | FNTA (0.57) | FNTAFNTBPGGT1B | |
| SCHEMBL7585240 | 0.72 | PTGS2 (0.43) | FNTAFNTBPTGS2CYP19A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025088-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-09-05 | — | — | EP | disclosed |