Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 2/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.30 |
| ▸ | CTSA | P10619 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561786 | 0.89 | KDM5A (0.35) | CYP11B1CYP11B2CAPN1KDM5AKDM4C | |
| SCHEMBL7570258 | 0.86 | CYP11B1 (0.34) | CYP11B1CYP11B2CAPN1KDM5AKDM4C | |
| SCHEMBL7863527 | 0.84 | NAMPT (0.31) | CYP11B1CYP11B2KDM5AKDM4CKDM5B | |
| SCHEMBL7564001 | 0.81 | CYP11B1 (0.36) | CYP11B1CYP11B2CAPN1KDM5AKDM4C | |
| SCHEMBL7567637 | 0.79 | CYP11B1 (0.36) | CYP11B1CYP11B2CAPN1CTSA | |
| SCHEMBL7561796 | 0.79 | CTSA (0.33) | CYP11B1CYP11B2KDM5AKDM4CKDM5B | |
| SCHEMBL7567718 | 0.78 | FNTA (0.32) | CAPN1 | |
| SCHEMBL7561389 | 0.77 | CTSA (0.36) | CYP11B1CYP11B2CAPN1CTSA | |
| SCHEMBL7562561 | 0.76 | ITGB3 (0.33) | CAPN1 | |
| SCHEMBL7563740 | 0.76 | FNTA (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025088-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-09-05 | — | — | EP | disclosed |