Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 2/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.30 |
| ▸ | CTSA | P10619 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561796 | 0.85 | CTSA (0.33) | NAMPTCYP11B1CYP11B2KDM5AKDM4C | |
| SCHEMBL7863524 | 0.84 | CYP11B1 (0.31) | CYP11B1CYP11B2KDM5AKDM4CKDM5B | |
| SCHEMBL7561786 | 0.80 | KDM5A (0.35) | NAMPTCYP11B1CYP11B2KDM5AKDM4C | |
| SCHEMBL7570258 | 0.79 | CYP11B1 (0.34) | NAMPTCYP11B1CYP11B2KDM5AKDM4C | |
| SCHEMBL7564011 | 0.78 | CYP11B1 (0.35) | NAMPTCYP11B1CYP11B2CTSA | |
| SCHEMBL7864451 | 0.76 | CTSA (0.35) | CYP11B1CYP11B2KDM5AKDM4CKDM5B | |
| SCHEMBL7567735 | 0.75 | FNTA (0.31) | — | |
| SCHEMBL7867264 | 0.73 | — | — | |
| SCHEMBL7561395 | 0.73 | CTSA (0.38) | NAMPTCTSA | |
| SCHEMBL7563752 | 0.73 | FNTA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025088-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-09-05 | — | — | EP | disclosed |