Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 7/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6514570 | 0.92 | PTGS2 (0.58) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL7863781 | 0.84 | PTGS2 (0.55) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL6513520 | 0.83 | PTGS2 (0.71) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL6514510 | 0.79 | PDPK1 (0.73) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL6728774 | 0.78 | PTGS2 (0.74) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL6516201 | 0.78 | PTGS2 (0.57) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL6723125 | 0.77 | PTGS2 (0.64) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL6722834 | 0.77 | PTGS2 (0.73) | PTGS2PTGS1CYP2C9PDPK1PTGES | |
| SCHEMBL6514073 | 0.77 | PTGS2 (0.65) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL6721918 | 0.77 | PTGS2 (0.65) | PTGS2PTGS1CYP2C9PDPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086097-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER INC. (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999064415-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-12-16 | — | — | WO | claimed |