Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6736164 | 0.89 | CHRM2 (0.40) | HDAC8CA2CA1MEN1KMT2A | |
| SCHEMBL7856922 | 0.85 | ESRRG (0.45) | HDAC8CA2CA1MEN1KMT2A | |
| SCHEMBL1178025 | 0.84 | MAOA (0.46) | HDAC8MAOAMAOBCYP19A1GRM2 | |
| SCHEMBL15264208 | 0.80 | SMN1; SMN2 (0.49) | HDAC8MAOAMAOBCYP19A1KCNH2 | |
| SCHEMBL8419438 | 0.79 | SIGMAR1 (0.54) | ADRB2DRD3 | |
| SCHEMBL1718277 | 0.78 | NQO2 (0.51) | MAOAMAOBCA2CA1NOX4 | |
| SCHEMBL3041791 | 0.78 | TAAR1 (0.49) | MEN1KMT2AOPRK1 | |
| SCHEMBL7141839 | 0.76 | CA12 (0.50) | MEN1KMT2ALTA4HDRD3 | |
| SCHEMBL3131556 | 0.76 | SIGMAR1 (0.48) | CA2CA1 | |
| SCHEMBL6180823 | 0.76 | SLC7A5 (0.45) | MAOAMAOBCYP19A1GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077935-A1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058499-A1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 1999-11-18 | — | — | WO | disclosed |