Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 16/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784338 | 1.00 | MAPT (0.64) | MAPTALDH1A1LMNAALOX12SMN1; SMN2 | |
| SCHEMBL6811647 | 0.87 | MAPT (0.55) | MAPTALDH1A1SMN1; SMN2HTTKDM4E | |
| SCHEMBL6811645 | 0.87 | MAPT (0.55) | MAPTALDH1A1SMN1; SMN2HTTKDM4E | |
| SCHEMBL7784341 | 0.86 | MAPT (0.49) | MAPTALDH1A1LMNAALOX12SMN1; SMN2 | |
| SCHEMBL29778327 | 0.80 | NPC1 (0.46) | SMN1; SMN2HTTPKMNPC1RAB9A | |
| SCHEMBL6811343 | 0.80 | NPC1 (0.46) | SMN1; SMN2HTTPKMNPC1RAB9A | |
| SCHEMBL6811346 | 0.80 | NPC1 (0.46) | SMN1; SMN2HTTPKMNPC1RAB9A | |
| SCHEMBL15597543 | 0.73 | L3MBTL1 (0.62) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL12980 | 0.70 | ADRB1 (0.62) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL27485349 | 0.70 | GSK3B (0.47) | MAPTALDH1A1LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137632-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000034238-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |