Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863764 | 0.84 | REN (0.58) | RENKCNH2CYP3A4IKBKB | |
| SCHEMBL7872769 | 0.83 | REN (0.55) | RENKCNH2CYP3A4IKBKB | |
| SCHEMBL7870969 | 0.83 | REN (0.49) | RENKCNH2CYP3A4IKBKB | |
| SCHEMBL7863795 | 0.83 | REN (0.54) | RENKCNH2CYP3A4IKBKB | |
| SCHEMBL10202498 | 0.82 | REN (0.53) | RENKCNH2LMNAHPGDCYP3A4 | |
| SCHEMBL7865871 | 0.80 | REN (0.48) | RENKCNH2CYP3A4IKBKB | |
| SCHEMBL7867634 | 0.78 | REN (0.44) | RENKCNH2CYP3A4 | |
| SCHEMBL7872529 | 0.77 | REN (0.41) | RENKCNH2IKBKB | |
| SCHEMBL7863962 | 0.75 | HTR2A (0.43) | RENKCNH2 | |
| SCHEMBL7862530 | 0.74 | REN (0.63) | RENKCNH2CYP3A4IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |