Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863795 | 0.90 | REN (0.54) | RENKCNH2CYP3A4IKBKB | |
| SCHEMBL7870969 | 0.90 | REN (0.49) | RENKCNH2CYP3A4IKBKB | |
| SCHEMBL7872769 | 0.90 | REN (0.55) | RENKCNH2CYP3A4IKBKBMTNR1A | |
| SCHEMBL7865871 | 0.87 | REN (0.48) | RENKCNH2CYP3A4IKBKB | |
| SCHEMBL7867634 | 0.85 | REN (0.44) | RENKCNH2CYP3A4 | |
| SCHEMBL7863792 | 0.84 | REN (0.44) | RENKCNH2CYP3A4IKBKB | |
| SCHEMBL7872529 | 0.84 | REN (0.41) | RENKCNH2IKBKB | |
| SCHEMBL7872527 | 0.83 | REN (0.61) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL534760 | 0.82 | REN (0.60) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL7862530 | 0.81 | REN (0.63) | RENKCNH2CYP3A4IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |