SCHEMBL7863961

SCHEMBL7863961

CON=CCc1ccc(C#N)cc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.47
LOXL2 Q9Y4K0 2/20 0.44
MAOB P27338 5/20 0.44
MAOA P21397 3/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
GAA P10253 2/20 0.43
IDO1 P14902 2/20 0.42
KCNJ1 P48048 1/20 0.40
KCNH2 Q12809 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.38
ALDH1A1 P00352 2/20 0.38
HTT P42858 1/20 0.37
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CYP19A1 P11511 1/20 0.36
KDM4E B2RXH2 1/20 0.36
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7868577 0.80 GLA (0.43) ALDH1A1HTTTSHRCYP19A1
SCHEMBL6076750 0.76 KDM4E (0.49) LOXL2MAOBSMN1; SMN2IDO1ALDH1A1
SCHEMBL6570431 0.76 ALDH1A1 (0.33) SMN1; SMN2ALDH1A1TSHRKDM4ELMNA
SCHEMBL27922464 0.76 CYP2A6 (0.52) CYP2A6LOXL2MAOBMAOANPC1
SCHEMBL16587900 0.76 IDO1 (0.43) IDO1ALDH1A1LMNA
SCHEMBL1444575 0.76 KDM4E (0.49) LOXL2MAOBSMN1; SMN2IDO1ALDH1A1
SCHEMBL15540864 0.76 TDP1 (0.39) LOXL2MAOBMAOASMN1; SMN2IDO1
SCHEMBL15539899 0.76 TDP1 (0.39) LOXL2MAOBMAOASMN1; SMN2IDO1
SCHEMBL15540331 0.76 TDP1 (0.39) LOXL2MAOBMAOASMN1; SMN2IDO1
SCHEMBL9278957 0.75 MAOB (0.46) MAOBNPC1IDO1ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140913-A1 THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-10 EP disclosed
EP-1137632-A1 THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-04 EP disclosed
WO-2000034269-A1 THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed
WO-2000034238-A1 THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed