Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | KCNB1 | Q14721 | 4/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712445 | 0.86 | PTGDR2 (0.44) | ADRB2SMPD3PTGDR2TRPM4LOXL2 | |
| SCHEMBL3712377 | 0.81 | TRPM4 (0.48) | ADRB2PTGDR2TRPM4LOXL2HDAC2 | |
| SCHEMBL7907897 | 0.72 | MAPK14 (0.45) | ADRB2SMPD3PTGDR2TRPM4MAPK14 | |
| Ethoxycarbonyl Group SCHEMBL29291640 | 0.68 | ADRB2 (0.47) | ADRB2SMPD3PTGDR2LOXL2HDAC2 | |
| SCHEMBL8240124 | 0.67 | LOXL2 (0.67) | ADRB2SMPD3LOXL2ABL1BCR | |
| SCHEMBL13728050 | 0.67 | LOXL2 (0.57) | ADRB2PTGDR2LOXL2HDAC2FFAR1 | |
| SCHEMBL3722096 | 0.67 | TRPM4 (0.47) | ADRB2PTGDR2TRPM4LOXL2MAPK14 | |
| SCHEMBL8232408 | 0.67 | CHEK2 (0.47) | ADRB2PTGDR2LOXL2HDAC2LRRK2 | |
| SCHEMBL25735777 | 0.67 | LOXL2 (0.61) | ADRB2SMPD3PTGDR2LOXL2FFAR1 | |
| SCHEMBL27666818 | 0.66 | EGFR (0.51) | ADRB2SMPD3PTGDR2LOXL2KCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118208-A1 | BENZOXAZEPIN-4- (5H) -YL DERIVATIVES AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |