Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | IL2 | P60568 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375324 | 0.81 | LMNA (0.36) | LMNAMAPTHTTKDM4EHRH3 | |
| SCHEMBL5363532 | 0.80 | LMNA (0.40) | LMNAMAPTHTTKDM4EHRH3 | |
| SCHEMBL5378874 | 0.76 | KIF11 (0.42) | LMNAMAPTHTTKDM4EHRH3 | |
| SCHEMBL2557980 | 0.75 | HRH3 (0.40) | LMNAMAPTHTTKDM4EHRH3 | |
| SCHEMBL1621903 | 0.75 | KDM4E (0.50) | LMNAMAPTHTTKDM4EMGLL | |
| SCHEMBL5583063 | 0.74 | KDM4E (0.47) | LMNAMAPTHTTKDM4EMGLL | |
| SCHEMBL954192 | 0.74 | LMNA (0.48) | LMNAMAPTHTTKDM4EHRH3 | |
| SCHEMBL422974 | 0.73 | KDM4E (0.42) | LMNAMAPTHTTKDM4EHRH3 | |
| SCHEMBL4462971 | 0.73 | KDM4E (0.55) | LMNAMAPTHTTKDM4EHRH3 | |
| SCHEMBL14351661 | 0.72 | KDM4E (0.45) | LMNAMAPTHTTKDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140924-A1 | PIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035915-A1 | PIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-06-22 | — | — | WO | disclosed |