Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.43 |
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.43 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.43 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.43 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.43 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.43 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7864705 | 1.00 | KDM4E (0.46) | KDM4EPOLBLMNAALDH1A1CYP3A4 | |
| Diisopromine SCHEMBL27588785 | 0.85 | KDM4E (0.55) | KDM4EPOLBLMNAALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL6939360 | 0.78 | MAOB (0.48) | ALDH1A1MAOB | |
| Fumaric Acid SCHEMBL6939350 | 0.78 | MAOB (0.48) | ALDH1A1MAOB | |
| Diisopromine SCHEMBL25648 | 0.72 | HRH1 (0.63) | LMNAALDH1A1CYP3A4CYP2C19CHRM2 | |
| Tolterodine SCHEMBL1260791 | 0.72 | CHRM3 (0.84) | KDM4EPOLBLMNAALDH1A1CYP3A4 | |
| SCHEMBL6938104 | 0.72 | CCR5 (0.40) | CYP2C19MAOB | |
| Fumaric Acid SCHEMBL5178945 | 0.71 | CHRM3 (0.64) | KDM4EPOLBLMNAALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL5178943 | 0.71 | CHRM3 (0.64) | KDM4EPOLBLMNAALDH1A1CYP3A4 | |
| Fumaric Acid SCHEMBL5178957 | 0.71 | CHRM3 (0.64) | KDM4EPOLBLMNAALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100482635-C | Noval compounds, their use and preparation | PFIZER HEALTH AB (SE) | 2009-04-29 | — | — | CN | disclosed |
| CN-1636967-A | Noval compounds, their use and preparation | PFIZER (SE) | 2005-07-13 | — | — | CN | disclosed |
| US-6313132-B1 | FOR THERAPY OF URINARY INCONTINENCE, ACETYLCHOLINE-MEDIATED DISORDER | PHARMACIA AB (SE) | 2001-11-06 | — | — | US | disclosed |
| EP-1019358-A1 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | Pharmacia & Upjohn AB (SE) | 2000-07-19 | — | — | EP | disclosed |
| CN-1251569-A | Novel compounds, their use and process for their preparation | PHARMACIA & UPJOHN AB (SE) | 2000-04-26 | — | — | CN | disclosed |
| WO-1998043942-A1 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | PHARMACIA & UPJOHN AB (SE) | 1998-10-08 | — | — | WO | disclosed |