SCHEMBL7864883

SCHEMBL7864883

O=C(CC(CCN1C(=O)c2ccccc2C1=O)C(=O)O)c1ccc(C#CCOc2ccccc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 17/20 0.45
MMP9 P14780 17/20 0.45
MMP3 P08254 3/20 0.45
MMP13 P45452 3/20 0.45
MMP1 P03956 3/20 0.45
ADAM17 P78536 3/20 0.43
ADAM10 O14672 2/20 0.42
MMP14 P50281 2/20 0.42
MAPT P10636 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7860511 0.88 MMP2 (0.47) MMP2MMP9MMP3MMP13MMP1
SCHEMBL8482551 0.85 MMP2 (0.52) MMP2MMP9MMP3MMP13MMP1
SCHEMBL7861855 0.83 MMP2 (0.44) MMP2MMP9MMP3MMP13MMP1
SCHEMBL10021381 0.83 MMP2 (0.50) MMP2MMP9MMP3MMP13MMP1
SCHEMBL7862695 0.83 MMP2 (0.50) MMP2MMP9MMP3MMP13MMP1
SCHEMBL8480599 0.82 MMP2 (0.48) MMP2MMP9MMP3MMP13MMP1
SCHEMBL7860408 0.82 MMP2 (0.51) MMP2MMP9MMP3MMP13
SCHEMBL7865130 0.82 MMP2 (0.51) MMP2MMP9MMP3MMP13
SCHEMBL7865124 0.81 TSHR (0.58) MMP2MMP9MMP3MMP13MMP1
SCHEMBL7861661 0.80 NPC1 (0.62) MMP2MMP9MMP3MMP13MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923529-B1 SUBSTITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS BAYER AG (US) 2001-09-19 EP claimed
EP-0923529-A1 SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS Bayer Corporation (US) 1999-06-23 EP claimed
WO-1997043237-A1 SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS BAYER CORPORATION (US) 1997-11-20 WO claimed
EP-0923529-B1 SUBSTITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS BAYER AG (US) 2001-09-19 EP disclosed
WO-2000056283-A1 INHIBITION OF MATRIX METALLOPROTEINASES WITH POLYMERS AND PHARMACEUTICAL APPLICATIONS THEREOF THE B.F.GOODRICH COMPANY (US) 2000-09-28 WO disclosed
EP-0923529-A1 SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS Bayer Corporation (US) 1999-06-23 EP disclosed
US-5863915-A ENZYME INHIBITORS FOR BONES AND JOINTS BAYER CORPORATION (US) 1999-01-26 US disclosed
WO-1997043237-A1 SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS BAYER CORPORATION (US) 1997-11-20 WO disclosed