Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 9/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865024 | 1.00 | HRH1 (0.44) | HRH1KDM4EKCNH2CHRM1NR1H2 | |
| SCHEMBL7862634 | 0.84 | HRH1 (0.43) | HRH1KDM4EKCNH2 | |
| SCHEMBL8714245 | 0.84 | HRH1 (0.43) | HRH1KDM4EKCNH2 | |
| SCHEMBL7862632 | 0.84 | HRH1 (0.43) | HRH1KDM4EKCNH2 | |
| SCHEMBL9535375 | 0.76 | HRH1 (0.55) | HRH1KDM4EKCNH2CHRM1 | |
| SCHEMBL7861655 | 0.75 | HRH1 (0.48) | HRH1KDM4EKCNH2CHRM1 | |
| SCHEMBL7861658 | 0.75 | HRH1 (0.48) | HRH1KDM4EKCNH2CHRM1 | |
| SCHEMBL7864920 | 0.74 | HRH1 (0.45) | HRH1KDM4EKCNH2 | |
| SCHEMBL7864916 | 0.74 | HRH1 (0.45) | HRH1KDM4EKCNH2 | |
| SCHEMBL7864923 | 0.74 | HRH1 (0.45) | HRH1KDM4EKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869955-B1 | N-ACYL-2-SUBSTITUTED-4-(BENZIMIDAZOLYL- OR IMIDAZOPYRIDINYL-SUBSTITUTED RESIDUES)-PIPERIDINES AS TACHYKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-24 | — | — | EP | disclosed |
| US-6110939-A | AS A SUBSTANCE P ANTAGONISTS TREATING TACHYKININ-MEDIATED DISEASE, ASTHMA, CENTRAL NERVOUS SYSTEM DISORDER | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-08-29 | — | — | US | disclosed |