Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19924890 | 0.85 | HRH1 (0.74) | HRH1KDM4EKCNH2CHRM1 | |
| SCHEMBL9535563 | 0.82 | TP53 (0.51) | HRH1KCNH2CHRM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7985310 | 0.82 | KDM4E (0.56) | HRH1KDM4EKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL8138397 | 0.81 | ALDH1A1 (0.43) | KDM4ECHRM1ALDH1A1HSD17B10MAPT | |
| SCHEMBL8566268 | 0.80 | ALDH1A1 (0.42) | HRH1KDM4ECHRM1ALDH1A1HSD17B10 | |
| SCHEMBL9536951 | 0.79 | KDM4E (0.53) | HRH1KDM4EKCNH2ALDH1A1HSD17B10 | |
| SCHEMBL6597555 | 0.77 | ALDH1A1 (0.59) | ALDH1A1 | |
| SCHEMBL992547 | 0.76 | HRH1 (0.66) | HRH1KDM4EKCNH2CHRM1ALDH1A1 | |
| SCHEMBL7865017 | 0.76 | HRH1 (0.44) | HRH1KDM4EKCNH2CHRM1 | |
| SCHEMBL7865024 | 0.76 | HRH1 (0.44) | HRH1KDM4EKCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |
| US-4943580-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | disclosed |