Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 10/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | TSPO | P30536 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 9/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865623 | 0.91 | HTT (0.47) | HTTMEN1KMT2ANPC1LMNA | |
| SCHEMBL6816721 | 0.91 | HTT (0.47) | HTTMEN1KMT2ANPC1LMNA | |
| SCHEMBL6817172 | 0.87 | CXCR2 (0.60) | HTTMEN1KMT2ANPC1LMNA | |
| SCHEMBL6817174 | 0.82 | CXCR2 (0.60) | HTTMEN1KMT2ANPC1LMNA | |
| SCHEMBL30669533 | 0.73 | CSNK2A1 (0.56) | MEN1KMT2ATDP1GAAMAPT | |
| SCHEMBL29116821 | 0.73 | CSNK2A1 (0.56) | MEN1KMT2ATDP1GAAMAPT | |
| SCHEMBL13235126 | 0.71 | HTT (0.81) | HTTMEN1KMT2ANPC1LMNA | |
| SCHEMBL27576136 | 0.70 | PARP1 (0.40) | MEN1KMT2ATDP1GAAMAPT | |
| SCHEMBL6816898 | 0.68 | CSNK2A1 (0.50) | MEN1KMT2ATDP1GAAMAPT | |
| SCHEMBL5595017 | 0.67 | CXCR1 (0.68) | HTTMEN1KMT2ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300325-B1 | HETEROCYCLIC RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM CORPORATION | 2001-10-09 | — | — | US | disclosed |