Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CD4 | P01730 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594215 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1LMNATSHRHTR2A | |
| SCHEMBL5336401 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1LMNATSHRHTR2A | |
| SCHEMBL7594219 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LMNATSHRHTR2A | |
| SCHEMBL7598485 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LMNATSHRHTR2A | |
| SCHEMBL7598488 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LMNATSHRHTR2A | |
| SCHEMBL7594987 | 0.77 | HDAC8 (0.42) | LMNAHDAC8POLBACHE | |
| SCHEMBL9387794 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1LMNATSHRHTR2A | |
| SCHEMBL7598492 | 0.76 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNATSHRHTR2A | |
| SCHEMBL251631 | 0.76 | ACHE (0.53) | SMN1; SMN2DRD2ACHE | |
| SCHEMBL7596216 | 0.75 | HDAC8 (0.44) | LMNAHDAC8POLBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303633-B1 | FOR THERAPY AND PROPHYLAXIS OF ALZHEIMER'S DISEASE | PFIZER INC | 2001-10-16 | — | — | US | disclosed |
| US-6124321-A | Heteroaryl amines as novel acetyl cholinesterase inhibitors | PFIZER INC (US) | 2000-09-26 | — | — | US | disclosed |
| US-5965574-A | Heteroaryl amines as novel acetylcholinesterase inhibitors | CHEN YUHPYNG LIANG (US) | 1999-10-12 | — | — | US | disclosed |
| US-5574046-A | Heteroaryl amines as novel acetylcholinesterase inhibitors | PFIZER INC. (US) | 1996-11-12 | — | — | US | disclosed |
| WO-1993007140-A1 | HETEROARYL AMINES AS NOVEL ACETYL CHOLINESTERASE INHIBITORS | PFIZER INC. (US) | 1993-04-15 | — | — | WO | disclosed |