Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814286 | 0.89 | CES2 (0.53) | CES2KDM4ECFTRMAPTGAA | |
| SCHEMBL6814288 | 0.89 | CES2 (0.53) | CES2KDM4ECFTRMAPTGAA | |
| SCHEMBL7865746 | 0.84 | POLB (0.32) | CES2KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL6815360 | 0.82 | MAPT (0.42) | KDM4ELMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL6815355 | 0.82 | MAPT (0.42) | KDM4ELMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL7871958 | 0.79 | MEN1 (0.40) | CES2LMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL6815686 | 0.75 | GAA (0.44) | CES2KDM4EHTTSMN1; SMN2CFTR | |
| SCHEMBL6815688 | 0.75 | GAA (0.44) | CES2KDM4EHTTSMN1; SMN2CFTR | |
| SCHEMBL6814976 | 0.75 | KMT2A (0.39) | CES2KDM4ELMNASMN1; SMN2MAPT | |
| SCHEMBL6814979 | 0.75 | KMT2A (0.39) | CES2KDM4ELMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140913-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000034269-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |