Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 6/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | USP14 | P54578 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7866233 | 0.91 | DRD2 (0.46) | DRD2SLC6A4HRH3DRD3KDM2B | |
| Oxalic Acid SCHEMBL7870888 | 0.78 | DRD2 (0.46) | DRD2SLC6A4HRH3DRD3KDM2B | |
| Oxalic Acid SCHEMBL7865105 | 0.77 | HRH3 (0.44) | DRD2HRH3DRD3KDM2BDRD4 | |
| Oxalic Acid SCHEMBL7870894 | 0.77 | CHRNA7 (0.43) | DRD2SLC6A4HRH3DRD3KDM2B | |
| Oxalic Acid SCHEMBL7864905 | 0.76 | DRD2 (0.46) | DRD2SLC6A4HRH3DRD3KDM2B | |
| Maleic Acid SCHEMBL8819087 | 0.76 | F10 (0.34) | HRH3UTS2R | |
| Oxalic Acid SCHEMBL7867436 | 0.75 | HRH3 (0.44) | DRD2HRH3DRD3KDM2BDRD4 | |
| Phosphoric Acid SCHEMBL7867952 | 0.72 | DRD2 (0.45) | DRD2SLC6A4CHRNA7 | |
| Oxalic Acid SCHEMBL7867572 | 0.72 | SLC6A4 (0.50) | DRD2SLC6A4HRH3 | |
| SCHEMBL23367743 | 0.69 | HRH3 (0.60) | DRD2HRH3DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |