Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | DRD4 | P21917 | 4/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 6/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | PYGM | P11217 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7867436 | 0.91 | HRH3 (0.44) | HRH3DRD2DRD3DRD4CHEK1 | |
| Oxalic Acid SCHEMBL7864922 | 0.77 | DRD4 (0.40) | DRD2DRD3DRD4 | |
| Oxalic Acid SCHEMBL7867428 | 0.77 | CCNT1 (0.42) | HRH3DRD2DRD3DRD4CHEK1 | |
| Oxalic Acid SCHEMBL7866271 | 0.77 | DRD2 (0.46) | HRH3DRD2DRD3DRD4KDM2B | |
| Oxalic Acid SCHEMBL7867572 | 0.75 | SLC6A4 (0.50) | HRH3DRD2 | |
| Oxalic Acid SCHEMBL7866233 | 0.75 | DRD2 (0.46) | HRH3DRD2DRD3KDM2B | |
| Oxalic Acid SCHEMBL7868026 | 0.74 | CYP19A1 (0.44) | DRD2DRD3DRD4CHEK1ALK | |
| Phosphoric Acid SCHEMBL7864824 | 0.73 | SYK (0.36) | TLR9TLR7 | |
| SCHEMBL7865108 | 0.72 | HRH3 (0.45) | HRH3DRD2DRD3TLR9TLR7 | |
| SCHEMBL8870689 | 0.72 | HTR1A (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |