Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6333046 | 0.88 | LMNA (0.44) | TP53LMNAKDM4ETSHRHPGD | |
| SCHEMBL1278389 | 0.81 | TBXAS1 (0.48) | LMNATSHRHPGDMEN1KMT2A | |
| SCHEMBL5512391 | 0.74 | TBXAS1 (0.56) | LMNATSHR | |
| SCHEMBL26091147 | 0.74 | TSHR (0.54) | LMNATSHRMEN1KMT2AALDH1A1 | |
| Urea SCHEMBL28086323 | 0.74 | NPC1 (0.47) | LMNAKDM4EMEN1KMT2AALDH1A1 | |
| Urea SCHEMBL27857769 | 0.73 | TP53 (0.41) | TP53LMNATSHRHPGDMEN1 | |
| SCHEMBL5829664 | 0.73 | TBXAS1 (0.59) | LMNATSHRALDH1A1 | |
| SCHEMBL608651 | 0.73 | TBXAS1 (0.59) | LMNATSHRALDH1A1 | |
| SCHEMBL2287581 | 0.73 | TBXAS1 (0.59) | LMNATSHRALDH1A1 | |
| SCHEMBL31016264 | 0.73 | TBXAS1 (0.59) | LMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323344-B1 | HYDROLYZING 5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXAMIDES COMPOUND IN PRESENCE OF STRONG BASE TO FORM KETOROLAC | SYNTEX (U.S.A.) INC. | 2001-11-27 | — | — | US | disclosed |
| US-6197976-B1 | ACYLATION, SALT FORMATION, DEAMINATION | SYNTEX (U.S.A.) LLC | 2001-03-06 | — | — | US | disclosed |