Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 5/20 | 0.41 |
| ▸ | F7 | P08709 | 3/20 | 0.41 |
| ▸ | F3 | P13726 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874275 | 0.97 | F2 (0.41) | F2F7F3AURKBJAK3 | |
| Trifluoroacetic Acid SCHEMBL7874359 | 0.92 | TPSAB1 (0.38) | F2F7F3PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL7872481 | 0.91 | F2 (0.45) | F2F7F3AURKBPRSS1 | |
| Trifluoroacetic Acid SCHEMBL7874305 | 0.89 | F2 (0.35) | F2F7F3PRSS1PRSS2 | |
| SCHEMBL7874319 | 0.88 | F2 (0.47) | F2F7F3AURKBPRSS1 | |
| SCHEMBL7878820 | 0.87 | JAK3 (0.37) | F2F7F3JAK3PRSS1 | |
| SCHEMBL7878630 | 0.87 | KDM4E (0.40) | F2F7F3PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL7876019 | 0.86 | F2 (0.45) | F2PRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL7876053 | 0.86 | F2 (0.42) | F2F7F3PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL7872466 | 0.85 | ALDH1A1 (0.39) | ALDH1A1LMNAHTTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086122-A1 | PYRAZINONE PROTEASE INHIBITORS | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064446-A1 | PYRAZINONE PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-12-16 | — | — | WO | disclosed |