Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000439 | 0.78 | SLC6A4 (0.42) | SLC6A4HTR6 | |
| Bromide SCHEMBL7870832 | 0.77 | SLC6A4 (0.57) | SLC6A4HTR6DRD2 | |
| Oxalic Acid SCHEMBL7859566 | 0.76 | SLC6A4 (0.42) | SLC6A4HTR6DRD2DRD4 | |
| SCHEMBL6996625 | 0.76 | SLC6A4 (0.62) | SLC6A4HTR6 | |
| SCHEMBL11874262 | 0.75 | HTR6 (0.55) | SLC6A4HTR6DRD2DRD4 | |
| SCHEMBL6994397 | 0.73 | BLM (0.39) | MAPT | |
| SCHEMBL7867447 | 0.73 | SLC6A4 (0.45) | SLC6A4HTR6 | |
| Oxalic Acid SCHEMBL7865012 | 0.70 | SLC6A4 (0.40) | SLC6A4DRD2DRD4MAPT | |
| Benzoic Acid SCHEMBL7864856 | 0.70 | HTR6 (0.46) | SLC6A4HTR6 | |
| Bromide SCHEMBL7870911 | 0.70 | SLC6A4 (0.54) | SLC6A4HTR6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |