Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7867561 | 0.92 | HTR1D (0.40) | SLC6A4KDM4ELMNAALOX15HTR1A | |
| Oxalic Acid SCHEMBL7867306 | 0.80 | SLC6A4 (0.66) | SLC6A4KDM4ELMNAALOX15HTR1A | |
| Oxalic Acid SCHEMBL7865005 | 0.79 | KDM4E (0.59) | SLC6A4KDM4ELMNAALOX15HTR1A | |
| Oxalic Acid SCHEMBL7868023 | 0.78 | KMT2A (0.42) | KDM4ELMNAALOX15HTR1FHTR1D | |
| Oxalic Acid SCHEMBL7864973 | 0.78 | KDM4E (0.43) | KDM4ELMNAALOX15HTR1AHTR1F | |
| Oxalic Acid SCHEMBL7867529 | 0.77 | CHRNA7 (0.38) | KDM4ELMNAALOX15HTR1FPARP1 | |
| Phosphoric Acid SCHEMBL7864828 | 0.74 | KDM4E (0.37) | KDM4ELMNAALOX15HTR1FHTR1D | |
| Oxalic Acid SCHEMBL7870888 | 0.74 | DRD2 (0.46) | SLC6A4HTR1ATP53MAPTHTR7 | |
| Oxalic Acid SCHEMBL7867999 | 0.73 | DRD2 (0.41) | SLC6A4KDM4ELMNAALOX15HTR1F | |
| Oxalic Acid SCHEMBL7868026 | 0.73 | CYP19A1 (0.44) | SLC6A4HTR1FALKPARP1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |