Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 6/20 | 0.36 |
| ▸ | QRFPR | Q96P65 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865255 | 0.90 | HDAC6 (0.40) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL7868061 | 0.81 | HDAC6 (0.57) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL1264207 | 0.76 | L3MBTL1 (0.51) | HDAC6HDAC8HDAC1 | |
| SCHEMBL7795333 | 0.75 | HDAC6 (0.59) | HDAC6QRFPRKCNH2CYP2D6KCNE1 | |
| SCHEMBL1263771 | 0.74 | L3MBTL1 (0.49) | HDAC6HDAC8HDAC1 | |
| SCHEMBL7796723 | 0.73 | HDAC6 (0.59) | HDAC6HDAC8HDAC3HDAC1QRFPR | |
| SCHEMBL12895882 | 0.65 | HDAC6 (0.58) | HDAC6HDAC8HDAC3HDAC1QRFPR | |
| SCHEMBL17960394 | 0.62 | HDAC6 (0.55) | HDAC6HDAC8HDAC3HDAC1PHGDH | |
| SCHEMBL12210501 | 0.61 | HDAC6 (0.67) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL30547733 | 0.60 | KDM4E (0.45) | PHGDHAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151318-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |