Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | PHGDH | O43175 | 6/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12894673 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL13895694 | 0.88 | SLC9A1 (0.42) | KDM4EALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL9613270 | 0.86 | HSD17B10 (0.62) | KDM4EALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL30790917 | 0.86 | HSD17B10 (0.62) | KDM4EALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL13881405 | 0.86 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL9613264 | 0.79 | THRB (0.61) | KDM4EALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL28238032 | 0.79 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL6086802 | 0.79 | CLK1 (0.61) | KDM4EALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL13415456 | 0.78 | RXFP1 (0.62) | KDM4EALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL4744999 | 0.78 | KDM4E (0.73) | KDM4EALDH1A1HPGDHSD17B10MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423435-B1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | UNIV VANDERBILT (US) | 2023-08-23 | — | — | EP | disclosed |