Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CFTR | P13569 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874545 | 0.94 | NLRP3 (0.60) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL7871657 | 0.94 | NLRP3 (0.63) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL7867710 | 0.93 | NLRP3 (0.54) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL7870543 | 0.92 | NLRP3 (0.51) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9018196 | 0.91 | NLRP3 (0.67) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL8869981 | 0.91 | NLRP3 (0.67) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL7871652 | 0.90 | NLRP3 (0.54) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL7869432 | 0.89 | EGFR (0.52) | NLRP3MEN1LMNACYP1A2CYP2D6 | |
| SCHEMBL7862882 | 0.89 | EGFR (0.52) | NLRP3MEN1LMNACYP1A2CYP2D6 | |
| SCHEMBL7869461 | 0.88 | TSHR (0.57) | NLRP3MEN1ALDH1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |